Articles tagged with: Models

New study highlights forgotten protein kinase in embryogenesis and cancer

Posted in Publications Published by Marianne Baker 18 January 2016

New study highlights forgotten protein kinase in embryogenesis and cancer

A new joint study by Dr Angus Cameron's research group in our Centre for Tumour Biology and Prof Peter Parker 's lab at the Francis Crick Institute shows that a previously unregarded group of protein kinases is important in development and could be a potential cancer drug target...

Funding secured to revolutionise personalised prostate cancer treatments

Posted in Grants & Awards Published by Marianne Baker 23 November 2015

3D tumour model to test anti-cancer viruses & drugs

Funding secured to revolutionise personalised prostate cancer treatments

Barts Charity have funded a new project led by Dr Gunnel Halldén in our Centre for Molecular Oncology. This work aims to develop a method to test new combinations of cancer treatments on prostate cancer.

Ultimately they hope to use the test for individual patients, to provide personalised therapies...

Small RNA molecule could be key to controlling obesity

Posted in Publications Published by Marianne Baker 27 August 2015

Small RNA molecule could be key to controlling obesity

Professor Christopher Heeschen's research group has found that microRNA-93 (MiR-93) can control obesity in mice.

Their promising results suggest this RNA molecule could be used as a treatment to restore insulin sensitivity and reduce obesity along with associated disease risks, including cancer...

Fruit Fly on the Wall

Posted in BCI Spotlight Articles Published by Marianne Baker 14 August 2015

Fruit Fly on the Wall

Our Early Career Researcher Dr Paulo Ribeiro supervises the Drosophila melanogaster fruit fly genetics research laboratory in the Centre for Tumour Biology.

Find out about flies in cancer research and what kind of projects are happening in the lab now...

SEARCHBreast: reducing the need for animal models in breast cancer research

Posted in Publications Published by Marianne Baker 23 July 2015

SEARCHBreast: reducing the need for animal models in breast cancer research

Researchers here at BCI have developed the secure searchable online tissue database called SEARCHBreast in line with the "Replacement, Refinement and Reduction" or 3Rs of animals in research.

More funding has become available to develop tools and techniques that avoid repeating animal experiments and to make the most of the results we already have...

Unmasking leukaemia cells: PD-L1 blockade to control blood cancer

Posted in Publications Published by Marianne Baker 14 July 2015

Unmasking leukaemia cells: PD-L1 blockade to control blood cancer

Two new papers from our Centre for Haemato-Oncology in the journal Blood show that boosting the immune system could help control Chronic Lymphocytic Leukaemia (CLL).

The studies focus on two proteins called “Programmed Death Ligand 1” (PD-L1) and Programmed Death 1” (PD-1), found on the surface of tumour and immune cells respectively...

Making anti-cancer viruses safer for ovarian cancer patients

Posted in Publications Published by Marianne Baker 24 June 2015

Making anti-cancer viruses safer for ovarian cancer patients

Dr Michelle Lockley's group has published a new study in Cancer Research showing exciting progress in the use of viruses to treat ovarian cancer.

They've found a way to potentially reduce inflammation by targeting an integrin on macrophage cells, which oncolytic viruses can bind to...

New understanding of stem cells in human colon lesions

Posted in Publications Published by Marianne Baker 13 March 2015

New understanding of stem cells in human colon lesions

Dr Ann-Marie Baker in our Centre for Tumour Biology has a new study published in Nature Scientific Reports, finding that the number and location of stem-like cells in the human colon differs between pre-cancerous lesion types...

A new strategy to improve cancer treatment: Vascular Promotion Therapy

Posted in BCI Spotlight Articles, Publications Published by Marianne Baker 06 February 2015

A new strategy to improve cancer treatment: Vascular Promotion Therapy

A paper published in Cancer Cell recently from Professor Kairbaan Hodivala-Dilke’s laboratory could mark the beginning of a new strategy in cancer treatment.

The new tactics, tested in models of solid lung and pancreatic tumours, achieved four major goals: improved drug delivery to tumour cells; reduced tumour growth; decreased tumour spread (metastasis); and extended survival...

Graham lab discovers human gut stem cells' "wiggle" behaviour: Cell Reports

Posted in Publications Published by Marianne Baker 07 August 2014

Graham lab discovers human gut stem cells'

Until now, little was known about how intestinal stem cells (iSCs) behave in the human gut; previous work has focused on mouse models and we have not been able to be sure of how this translates to humans.

A new study by Dr Trevor Graham in our Centre for Tumour Biology is the first to reveal how human iSCs divide and maintain crypt structures in the colon...

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