Tumour_Angiogenesis

Tumour Angiogenesis

Why we focus on Angiogenesis

Angiogenesis is the formation of new blood vessels from pre-existing ones and is  essential for cancer progression and metastasis.  Manipulating tumour angiogenesis could stop cancer growth and spread. Understanding the cellular and molecular basis of tumour angiogenesis will lead us to novel and improved ways to control cancer.

What we do

  • We aim to improve the understanding of the molecular regulation of tumour angiogenesis.
  • Since angiogenesis is a feature of all solid cancers, it is crucial that we unravel both the molecular and cellular basis of this process.
  • Our work provides essential insights into the critical functions of growth factor receptors, adhesion molecules and cytokines in the control of tumour angiogenesis in various cancer models. 
  • Importantly, we have discovered novel targets for angiogenic therapy that we aim will, one day, improve the treatment of human cancer.

Key Publications

  • Tavora et al. Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy. Nature. 2014; 2;514(7520): 112-6
  • Kostourou et al. FAK-heterozygous mice display enhanced tumour angiogenesis. Nat Commun. 2013; 4:2020
  • Reynolds et al.Enhanced pathological angiogenesis in mice lacking β3-integrin or β3- and β5-integrins.  Nature Medicine 2002;8: 27-34.
  • Reynolds et al. Stimulation of tumour growth and angiogenesis by low concentrations of integrin inhibitors in therapy-resistant tumoursNature Medicine  2009;15: 392-400.

Who does the research

→ Click here for BCI researchers working on angiogenesis

Major Funders

  • BBSRC
  • Breast Cancer Campaign
  • Cancer Research UK
  • EU
  • Medical Research Council
  • Ovarian Cancer Action
  • Pancreatic Cancer Research Fund
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