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Pathology Services

Overview

Our Pathology Service offers a full range of histological techniques to all Barts Cancer Institute (BCI) centres. The lab provides a service to the researchers at BCI who are working on projects in understanding the links between cancer and inflammation; basic and applied PI3K signalling; cancer screening and prevention; therapeutic and diagnostic approaches to cancer; and the roles played by cytoadhesion in cancer spreading.

We also provide a service to other QMUL departments and to external users.

Key Services

  • Frozen tissue - processing and cutting of sections.
  • Fixed tissue - processing (embedding in paraffin wax) and cutting of sections.
  • Haematoxylin & Eosin (H&E) staining of frozen and paraffin sections.
  • Automated Immunohistochemistry (IHC) staining.

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How to book, advice & training

Please contact: bci-bci-pathology@qmul.ac.uk.

As well as providing a high quality service, we offer advice on existing procedures.
We are also open to collaborations on developing new procedures and techniques, so please get in touch about any potential new projects.

Sample drop-off/lab visiting hours:

  • 10:00 – 12:00
  • 14:00 – 16:00

Immunohistochemistry Examples

pathology_1

pathology_2Insulin_staining_of_human_pancreatic_islets_cells

pathology_3_Muscle_actin_monoclonal_on_mouse_intestine

pathology_4_Ki-67_on_mouse_colon_with_DAB_Map

Anti-HER2 staining on human breast cancer InIsulin staining of human pancreatic islets cells Muscle actin (monoclonal) on mouse intestine Ki-67 on mouse colon with DAB Map

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Equipment

The Pathology Service uses a range of equipment to automate all the steps from tissue processing to staining and has a Ventana Discovery and XT systems. For full details of our equipment, see below:

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Leica ST5010 autostainer and coverslipper

Autostainer XL and CV5030 - Coverslipper

The Leica Autostainer XL is a robotic staining system for performing all our H & E staining; this system can be adapted for other standard routine staining methods. Please enquire if any other standard staining is required.

The Autostainer is attached to a Leica CV5030 fully automated glass coverslipper. This produces slides with superior optical quality for reliable long-term storage. It is designed to coverslip microscope glass slides bearing tissue sections.

Leica ASP300 Tissue Processor

Fully enclosed tissue processor and is designed for routine and research histopathology.

path-leica asp3002

Leica RM2255 rotary microtome

Designed for fully motorised sectioning of paraffin embedded specimens, our service offers a broad application spectrum in routine and research histology specimens.

path-leica rm2255

Leica CM3050 S cryostat

Precise specimen orientation and specimen feed system via a step motor mechanism that ensures reproducible thin serial frozen sections of maximum quality.

path-leica cm30502

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