My research is focused on the links between cancer and inflammation, being especially interested in translating knowledge of cancer biology into new biological treatments for cancer and in the role that inflammatory cytokines play in cancer promotion. We study the tumour microenvironment of ovarian cancer using a platform of human multi-cellular tissue culture models and mouse models to research biological therapies that may prevent relapse and increase patient survival.
Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer. Cancer Immunol Res (2021) 9(6):665-681. PMID: 33839687
A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion. iScience (2021) 24(6):102676. PMID: 34189439
TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer. Cancer Res (2021) 81(22):5706-5719. PMID: 34561272
Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment. Cell Rep (2020) 30(2):525-540.e7. PMID: 31940494
Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers. Cancer Discov (2018) 8(3):304-319. PMID: 29196464
I am Professor of Cancer Biology at Barts Cancer Institute, Queen Mary University of London, where I am Deputy Centre Lead for the Centre for Tumour Microenvironment. I study the links between cancer and inflammation and research ways of translating this to clinical trial.
My key research areas of interest are:
Investigating the impact of London’s ultra low emission zone on children’s health: children’s health in London and Luton (CHILL) protocol for a prospective parallel cohort study Tsocheva I, Scales J, Dove R et al. BMC Pediatrics 23(10) 556
CD73 controls Myosin II–driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells Samain R, Maiques O, Monger J et al. Science Advances (2023) 9(10) eadi0244
Reciprocal Associations Between Science Efficacy, STEM Identity and Scientist Career Interest Among Adolescent Girls within the Context of Informal Science Learning Zhao M, Ozturk E, Law F et al. Journal of Youth and Adolescence (2024) 53(10) 472-484
Interferon epsilon and ovarian cancer Elorbany S, Malacrida B, Balkwill F Trends in Cancer (2023) 9(10) 985-986
Children's and adolescents’ evaluations of wealth‐related STEM inequality McGuire L, Marlow C, Hoffman AJ et al. Social Development (2024) 33(10)
Correction: A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma Phillips MM, Pavlyk I, Allen M et al. Pharmacological Reports (2023) 75(10) 753-753
Device-Measured Change in Physical Activity in Primary School Children During the UK COVID-19 Pandemic Lockdown: A Longitudinal Study Scales J, Chavda J, Ikeda E et al. Journal of Physical Activity and Health (2023) 20(10) 639-647
Abstract LB195: Immunotherapies that repolarize macrophages and CD4 T cells enhance the effect of chemotherapy in high-grade serous ovarian cancer Elorbany S, Berlato C, Carnevalli L et al. Cancer Research (2023) 83(10) lb195-lb195
The impact of pericytes on the stability of microvascular networks in response to nanoparticles Dibble M, Di Cio’ S, Luo P et al. Scientific Reports 13(10) 5729
Abstract 4551: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer: understanding the contribution of malignant cells Malacrida B, Elorbany S, Maniati E et al. Cancer Research (2023) 83(10) 4551-4551
For additional publications, please click herePostdoctoral Researchers in this group
Dr Eleni Maniati, Dr Ganga Gopinathan, Dr Florian Laforêts, Dr Beatrice Malacrida, Dr Panoraia Kotantaki, Dr Joash Joy
Clinical Research Fellows
Dr Owen Heath
PhD Students
Priyankaa Goordyal, Laura Lecker
Research Technician
Sam Nichols
BSU Technician
Colin Pegrum
In 2006, I was made a Fellow of the Academy of Medical Sciences, being elected a member of its Council later in the same year. I am a frequent plenary and keynote speaker at international meetings, such as Gordon and Keystone conferences and the American Association for Cancer Research (AACR).
I am also actively involved in communication of science to non-specialist audiences, especially young people. I have written thirteen science books for children on cell and molecular biology, with titles such as Enjoy Your Cells and The Egg and Sperm Race.
I am the Director of the Centre of the Cell, a biomedical science centre for children, educational website, and widening participation and outreach project in Whitechapel. The website was launched in March 2007 and the physical Centre opened in September 2009. As of July 2017 there have been over 171,000 participants in Centre of the Cell activities (www.centreofthecell.org).
I am a non-parliamentary board member of the Parliamentary Office of Science and Technology, POST and a Trustee of Bloodwise. I was awarded an OBE in the 2008 Queen's Birthday Honours list. In 2015 I was made a Doctor of Science honoris causa by the University of Bristol and in 2017 was awarded the Cancer Research UK Inspiring Leadership in Research Engagement Prize.