Professor Hemant Kocher

MBBS, MS, MD, FRCS
Centre: Tumour Biology
Professor of Liver & Pancreas Surgery
This email address is being protected from spambots. You need JavaScript enabled to view it.

QMUL Directory


I am a surgeon-scientist. My clinical research interests include tissue banking, clinical trials, innovative surgical techniques, epidemiology, meta-analysis and patient care pathways.

My translational research interests include pancreatic cancer stroma and tumour-stroma cross-talk including cell signalling, adhesion, metastasis, invasion leading to innovative therapies and novel biomarkers.

Research Details

Current research directions include:

  • Investigating the role of cytoskeletal proteins in pancreatic cancer progression, invasion and metastasis.
  • Investigating the role of pancreatic stellate cells, which are normally quiescent, but are activated in pancreatic cancer into highly proliferative myofibroblast-like cells which produce extracellular matrix components.
  • Developing organotypic pancreatic cancer models (three-dimensional in vitro systems for exploring interactions of the stroma with pancreatic cancer cells)
  • Developing novel clinical trials and biomarkers inspired by the laboratory results.
  • Biobanking Director: National Pancreas Registry and Tissue Bank

Clinical trials:

  • STARPAC (Study Chairman)
  • PRICKLE (Independent reviewer)

My clinical interests include clinical trials and epidemiology in patients with hepato-biliary-pancreatic disorders, surgical development, innovative surgical techniques, risk-assessment and quality improvement. My clinical practice is at the Barts and the London HPB Centre at the Royal London Hospital of Barts Health NHS Trust.

Profile

I joined the Barts Cancer Institute in February 2005 as a Senior Clinical Lecturer, having been awarded a National Clinician Scientist Fellowship by the National Institute of Health Research (UK). I completed my MD (Res) at King's College London under the supervision of Prof. Bruce M Hendry and Prof. Irving S Benjamin in 2003 and completed my specialist clinical training in hepato-biliary-pancreatic surgery under Prof. Nigel Heaton and Prof Mohammed Rela in 2005.

I qualified with numerous distinctions, awards and scholarships from University of Mumbai in 1993 and finished my surgical training in Mumbai (KEM Hospital) in 1996, leading to an award of MS (General Surgery) based on my work in "Immunomodulation in obstructive jaundice with Tinospora Cordifolia" (Best Thesis Award).

Funding

  • Pancreatic Cancer Research Fund
  • Medical Research Council
  • Barts Charity
  • Engineering and Physical Sciences Research Council
  • Cancer Research UK

Key Publications

Coleman SJ, Chioni A, Ghallab M, Anderson RK, Lemoine NR, Kocher HM§, Grose RP§. Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion. EMBO Mol Med 2014. 6(4):467-81.  PMID: 24503018 §Joint Senior authors

Li NF, Gemenetzidis E, Marshall FJ, Davies D, Yu Y, Frese K, Froeling FE, Woolf AK, Feakins RM, Naito Y, Iacobuzio-Donahue C, Tuveson DA, Hart IR, Kocher HM. RhoC interacts with integrin α5β1 and enhances its trafficking in migrating pancreatic carcinoma cells. PLOS ONE 2013. 8(12):e81575. PMID: 24312560 

Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J, Chelala C, Gribben JG, Ramsay AG, Kocher HM. Activated Pancreatic Stellate Cells Sequester CD8(+) T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma. Gastroenterology 2013. 145(5):1121-32. PMID: 23891972.

Kadaba R, Birke H, Wang J, Hooper S, Andl CD, Maggio FD, Soylu E, Ghallab M, Bor D, Froeling FE, Bhattacharya S, Rustgi AK, Sahai E, Chelala C, Sasieni P, Kocher HM. Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes. J Pathol. 2013 PMID: 23359139.


Further Publications

For additional publications, please click here.


I am a surgeon-scientist. My clinical research interests include tissue banking, clinical trials, innovative surgical techniques, epidemiology, meta-analysis and patient care pathways.

My translational research interests include pancreatic cancer stroma and tumour-stroma cross-talk including cell signalling, adhesion, metastasis, invasion leading to innovative therapies and novel biomarkers.

External Activities

  • National Cancer Intelligence Network (Upper GI and Pancreas)
  • Cancer Study group of British Society of Gastroenterology
  • Chairman Scientific Advisory Board, Pancreatic Cancer Action UK (charity)
  • Member, Scientific Advisory Committee, Worldwide Cancer Research
  • Member, Medical Advisory Committee, Pancreatic Cancer UK MDT co-Lead: Barts and the London HPB MDT

News

This site uses cookies in order to function properly. By continuing to browse, you agree that we can save them on your device. Privacy Policy.