Dr Jane Sosabowski

Dr Jane Sosabowski

BSc (Hons), MSc, PhD
Centre: Centre for Molecular Oncology
Senior Lecturer in Preclinical Molecular Imaging
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My main interests are in radiopharmaceutical development and the use of pre-clinical molecular imaging in drug development, especially biopharmaceuticals.

 

Research Details

I am particularly interested in imaging radiolabelled peptides and proteins for use in diagnosis and therapy of cancer.  These might be radiolabelled with positron emitters such as 68Ga or 64Cu in order to carry out PET imaging, 111In or 99mTc for SPECT imaging or with therapy radioisotopes such as 90Y and 177Lu.

The lab has a long-standing interest in imaging CCK-2 and GRP receptors which are overexpressed in a number of tumour types.

Drug development studies entail using imaging to show specific tissue targeting of small antibodies.  The aim is to use these targeting proteins to carry a therapeutic payload to the site of disease and this work is carried out in collaboration with GSK. We also use radioactive probes such as 18F-FDG and 18F-FLT to monitor response to treatment in vivo.

Profile

I graduated with a BSc(Hons) in Chemistry from University of Natal, Durban, South Africa and went on carry out an MSc by research into the Photochemistry of Sunscreen Constituents at same university.

I then moved to the UK to the Joint Department of Physics at the Institute of Cancer Research in Sutton, Surrey and completed my PhD looking at Development of PET radiotracers for the in vivo assessment of multidrug resistance. I then moved to the Nuclear Medicine Research Laboratory at Barts and the London School of Medicine and Dentistry to carry out a post doc under Prof Stephen Mather.

With the advent of pre-clinical imaging systems this lab developed into the Cancer Imaging Laboratory.

Funding

  • EPSRC PhD CASE studentship
  • Industrial collaborations with GSK and inviCRO
  • Cancer Research UK
  • Barts and the London Charity
  • External academic collaborations

Key Publications

Sosabowski, J. K., Matzow, T., Foster, J. M., Finucane, C., Ellison, D., Watson, S. A., and Mather, S. J. (2009) Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide. J Nucl Med 50, 2082-9. PMID: 19910426

Sosabowski, J. K., and Mather, S. J. (2006) Conjugation of DOTA-like chelating agents to peptides and radiolabeling with trivalent metallic isotopes. Nature Protocols 1, 972-976. PMID: 17406332

Naqvi, S. A., Matzow, T., Finucane, C., Nagra, S. A., Ishfaq, M. M., Mather, S. J., and Sosabowski, J. (2010) Insertion of a lysosomal enzyme cleavage site into the sequence of a radiolabeled neuropeptide influences cell trafficking in vitro and in vivo. Cancer Biother Radiopharm 25, 89-95. PMID: 20187801

Sosabowski, J. K., Lee, M., Dekker, B. A., Simmons, B. P., Singh, S., Beresford, H., Hagan, S. A., McKenzie, A. J., Mather, S. J., and Watson, S. A. (2007) Formulation development and manufacturing of a gastrin/CCK-2 receptor targeting peptide as an intermediate drug product for a clinical imaging study. Eur J Pharm Sci 31, 102-11. PMID: 17387005


Further Publications

For additional publications, please click here


My main interests are in radiopharmaceutical development and the use of pre-clinical molecular imaging in drug development, especially biopharmaceuticals.

 

See other researchers working on:

Imaging
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