Dr Li Jia

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Dr Li Jia

MB, PhD
Centre: Haemato-Oncology
Non-Clinical Senior Lecturer
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The research in my group focuses on the effects of the inflammatory microenvironment on disease progression and resistance to treatment in haematological malignancies.

Research Details

For over 20 years, my main research work focused on overcoming the resistance of leukaemia and lymphoma cells to chemo- or immuno-therapy, and the roles of mitochondria and BCL-2 family proteins in apoptotic cell death.

Our studies now focus on the impact of the inflammatory microenvironment on survival and treatment resistance mechanisms of chronic lymphocytic leukaemia (CLL) and B cell lymphoma.

Current research focuses are:

  • The roles of inflammatory microenvironment on CLL cell survival and resistance to novel anti-cancer drugs;
  • The impact of soluble inflammatory factors and their receptors on prognosis and clinical outcomes for patients with CLL;
  • Soluble inflammatory factor-mediated intracellular signalling network in malignant B-cells.

Profile

Education and Qualifications

  • 1994-1997: PhD in Cell Biology of Haematology. Department of Haematology, St. Bartholomew’s and The Royal London School of Medicine and Dentistry.
  • 1984-1985: Diploma in Advanced Biochemistry. NanKai University, Tianjin, China.
  • 1978-1983: Medical Bachelor (MB). China Medical University, Shenyang, China.

Career progression

  • Since Sept. 2008: Senior Lecturer. Centre for Haematological Oncology, Barts Cancer Institute, Queen Mary University of London.
  • Oct 2004-Aug 2008: Senior Lecturer. Centre for Haematology, Institute of Cell and Molecular Science.
    July 2000: Non-Clinical Lecturer and leader of the apoptosis laboratory. Centre for Haematology, Institute of Cell and Molecular Science.
  • 1997-1999: Post-doctoral Research Fellow. Department of Haematology, St. Bartholomew’s and The Royal London School of Medicine and Dentistry. Supported by Leukaemia Research Fund.
  • 1994-1996: Research Assistant and PhD student. Department of Haematology, St. Bartholomew’s and The Royal London School of Medicine and Dentistry.
  • 1989-1993: Associate Researcher Department of Biochemistry and Molecular Biology, Institute of Haematology and Blood Disease Hospital, Chinese Academy of Medical Sciences. P.R. China.
  • 1983-1989: Research Assistant. Department of Biochemistry and Molecular Biology, Institute of Haematology and Blood Disease Hospital, Chinese Academy of Medical Sciences.

Funding

  • 2015-2017: Kay Kendall Leukaemia Fund, UK
  • 2016-2019: National Natural Science Foundation, China
  • 2016-2019: CONACyT, (National Council of Science and Technology) Mexico
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    Key Publications

    Liu F, Jia L, Wang P, Farren T, Li H, Hao X, Agrawal SG. CD126 and targeted therapy with Tocilizumab in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2016. 15;22(10):2462-9. PMID: 26712690

    Zhao T, Ren H, Wang X, Liu P, Yan F, Jiang W, Li Y, Li J, Gribben JG, Jia L, Hao J. Rituximab-induced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large B-cell lymphoma. Oncotarget. 2015. 29;6(29):27816-31. PMID: 26315113

    McCarthy A, Marzec J, Clear A, Petty RD, Coutinho R, Matthews J, Wilson A, Iqbal S, Calaminici M, Gribben JG, Jia L. Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2. Oncotarget. 2014. 5(22):11653-68. PMID: 25362242

    Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia. Jia L., Clear A., Liu F.T., Matthews J., Uddin N., McCarthy A., Hoxha E., Durance C., Iqbal S., Gribben J.G. Blood. 2014. 123(11):1709-19. PMID: 24464016


    Further Publications

    For additional publications, please click here.


    The research in my group focuses on the effects of the inflammatory microenvironment on disease progression and resistance to treatment in haematological malignancies.

    External Activities

    News

    See other researchers working on:

    Blood cancers Cell Signalling Leukaemia Lymphoma Metabolism
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