Professor Nick Lemoine

MD, PhD, FRCPath, FMedSci
Centre: Molecular Oncology
Fellowships:
  • Fellow of the Academy of Medical Sciences
  • Fellow of the Royal College of Pathologists
BCI Director
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QMUL Directory


I am the Director of Barts Cancer Institute. My groups' primary research interests are in the genomics and molecular pathology of pancreatic cancer and the development of oncolytic virotherapy.

Genomics & Molecular Pathology Team

Professor Claude Chelala, Dr Tatjana Crnogorac-Jurcevic

Research Details

I work with Professor Claude Chelala and Dr Tatjana Crnogorac-Jurcevic on the genomics and molecular pathology of pancreatic cancer. We use global profiling approaches at the genomic and proteomic levels to identify targets that can be exploited for detection and treatment of this disease. We are also developing novel platforms and algorithms for the bioinformatic interrogation and interpretation of very large, multidimensional datasets.

I work with Professor Yaohe Wang and Dr Gunnel Halldén on the development of oncolytic virotherapy, an approach that uses adenoviruses and vaccinia viruses that selectively replicate within and kill cancer cells, but leave normal cells untouched. We are also working on defining the cell survival signalling circuits that determine the sensitivity of cancer cells to this approach. The role of the immune system in modulating viral replication and tumour cell destruction is the focus of a major new programme.

Profile

I was Professor of Molecular Pathology at Imperial College London, where I was Director of the Cancer Research UK Molecular Oncology Unit and the first Director of the National Translational Cancer Research Centre at Hammersmith Hospital. Before that, I held academic positions at the Royal Postgraduate Medical School, London and The University of Wales College of Medicine in Cardiff. I trained in medicine at St Bartholomew's Hospital Medical College where I qualified with the University of London Gold Medal in 1983, specialising in pathology and oncology with posts in London and Cardiff.

I recently stepped down as Chairman of the MRC Clinical Research & Career Development Panel and the National Institute of Health Research Clinician Scientist Appointments & Review Panel. I previously chaired the MRC Stem Cell Fellowship Panel, the CR-UK Clinician Scientist and Senior Clinician Fellowship Panel and the MRC Experimental Medicine Review Panel for the Molecular & Cellular Medicine Board. I have been a long-serving member of the Gene Therapy Advisory Committee at the Department of Health, as well as CR-UK Science Funding Committee, MRC Molecular & Cellular Medicine Board, CORE Scientific Advisory Board and many other scientific review committees.

I have been the Editor of the Nature Specialist Journal Gene Therapy since 1997, and my research into the molecular genetics of cancer and gene therapy is funded by programme grants from Cancer Research UK, Digestive Cancer Campaign and the European Union. I was elected a fellow of the Academy of Medical Sciences in 2006.

Funding

Current Research Funding

2016 - 2019 Medical Research Council Developmental Pathway Funding Scheme Programme Grant
£0.75M
2014 - 2017 Cancer Research UK Centre of Excellence Award (lead applicant with five others)
£3M
2011 - 2016 Technology Strategy Board Stratified Medicine Programme (academic lead applicant with Source BioScience plc and Illumina Inc)
£0.5M
2012 - 2017 Cancer Research UK/NIHR Experimental Cancer Medicine Centre (lead applicant with five others at Barts & Brighton/Uni Sussex)
£2M
2010 - 2016 Cancer Research UK Programme Grant: "Genomics & Molecular Pathology of Pancreatic Cancer"
£1.2M

Key Publications

Chard LS, Lemoine NR, Wang Y. (2015) New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer. Oncoimmunology 4: e1038689. PMID: 26405610

Hughes J et al. (2015) Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus. Gene Ther. 22: 476-484. PMID: 25876464

Chard L et al. (2015) A Vaccinia virus armed with interleukin-10 is a promising therapeutic agent for treatment of murine pancreatic cancer. Clin Cancer Res. 21: 405-416. PMID: 25416195

Haider S et al. (2014) A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. Genome Med 6:105. PMID: 25587357


Further Publications

For additional publications, please click here.


I am the Director of Barts Cancer Institute. My groups' primary research interests are in the genomics and molecular pathology of pancreatic cancer and the development of oncolytic virotherapy.

External Activities

National and International Committees (current)

  • MRC Stratified Medicine Scientific Expert Panel (Chair)
  • MRC-Innovate UK (Technology Strategy Board) Biocatalyst Major Awards Panel 2013-
  • NIHR Invention for Innovation Challenge Awards Panel (Chair)
  • NIHR Strategy Board
  • Irish Health Research Board/Medical Research Charities Advisory Panel (Chair)
  • Prostate Cancer UK Scientific Advisory Board (Chair)
  • Diabetes UK Scientific Advisory Board (Chair)
  • Pancreatic Cancer Research Fund Scientific Advisory Board (Chair)
  • Pancreatic Cancer UK Scientific Advisory Board (Vice-Chair)
  • International Cancer Genome Consortium (ICGC) Pancreatic Cancer Scientific Advisory Committee
  • Canadian Institute of Health Research Training Program in Molecular Pathology of Cancer Scientific Advisory Board
  • Lister Institute Scientific Advisory Committee
  • North-East Thames Advisory Committee on Clinical Excellence Awards

Trusteeship

  • Trustee, Medical Research Foundation (MRC’s independently managed charity)

External Scientific Activities

  • Visiting Professor of Molecular Oncology, Zhengzhou University, China
  • VCN Biosciences (Barcelona), Scientific Advisory Board
  • Source Bioscience plc, Scientific Advisory Board
  • Alexis Biotechnology Ltd, Scientific Advisory Board

Editorial Activities

  • Editor in Chief of Gene Therapy (Nature Specialist Journals) 1997-
  • Commissioning Editor of British Medical Bulletin
  • Science Advisory Board:
    • Journal of Pathology
  • Editorial Board (current):
    • Future Oncology
    • Current Opinion in Molecular Therapeutics

News

See other researchers working on:

Bioinformatics Pancreas Viruses
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