Unpicking the molecular mechanisms underlying angiocrine signalling.
Upon DNA-damaging therapy, blood vessels produce a cocktail of cytokines and chemokines – the angiocrine signal. Our laboratory recently published evidence that FAK can control this angiocrine signal and that this can help sensitise tumours to DNA-damaging therapy.
My work will identify other players in the regulation of angiocrine signaling using a CRISPR screen. I will also explore the molecular mechanisms underlying how FAK controls angiocrine signaling.