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Chromosomal instability in ovarian cancer
26th November 2020
We spoke with Dr Sarah McClelland and senior postdoctoral researcher in her group, Dr Nadeem Shaikh, about the team’s most recent paper, published in Cancer Research, which set out to explore the mechanisms of chromosomal instability in high-grade serous ovarian carcinoma – the most common type of ovarian cancer. The study sheds light on how these mechanisms may be able to be targeted to overcome treatment resistance in this cancer type.
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Protein powerhouses – Q&A with Dr Mardakheh
9th November 2020
We spoke with Dr Faraz Mardakheh from Barts Cancer Institute’s Centre for Cancer Cell and Molecular Biology about his most recent research paper, published today in Developmental Cell. The study sheds lights on how invasive cancer cells increase their protein-making capacity in order to boost their growth and invasive capabilities, and identifies a key player involved in this process, which may represent a target for therapeutic interventions.
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Protecting blood against premature ageing
9th November 2020
Researchers from Barts Cancer Institute, Queen Mary University of London, and the University of Edinburgh have discovered a key protein that supports the production of healthy blood cells throughout life by regulating the inflammatory response. This is the first study to identify a protein that directly keeps in check blood stem cells’ immune responses to protect them from excessive damage and premature ageing.
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Aggressive melanoma cells at edge of tumours are key to cancer spread
20th October 2020
Research led by Barts Cancer Institute, Queen Mary University of London, has revealed novel insights into the mechanisms employed by melanoma cells to form tumours at secondary sites around the body. The findings from the study may help to identify new targets to inhibit melanoma spread and guide treatment decisions in the clinic.
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Novel insights into graft-versus-host disease
13th October 2020
Research led by Barts Cancer Institute, Queen Mary University of London, has identified a subset of immune cells involved in site-specific tissue damage in cancer patients who have developed harmful graft-versus-host disease after stem cell transplantation. The insights gained from the study may help to define new targets for more selective approaches to prevent or treat this condition in patients who have received a stem cell transplant.
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Research explainer with Dr Gabriella Ficz
28th September 2020
We spoke with Dr Gabriela Ficz to find out about her recent publication in Nature Communications. The study set out to determine how embryonic stem cells can acquire features that are found in cancer cells.
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