Vilma Dembitz, Hannah Lawson, Richard Burt, Sirisha Natani, Céline Philippe, Sophie C. James, Samantha Atkinson, Jozef Durko, Lydia M. Wang, Joana Campos, Aoife M. S. Magee, Keith Woodley, Michael J. Austin, Ana Rio-Machin, Pedro Casado, Findlay Bewicke-Copley, Giovanny Rodriguez Blanco, Diego Pereira-Martins, Lieve Oudejans, Emeline Boet, Alex von Kriegsheim, Juerg Schwaller, Andrew J. Finch, Bela Patel, Jean-Emmanuel Sarry, Jerome Tamburini, Jan Jacob Schuringa, Lori Hazlehurst, John A. Copland III, Mariia Yuneva, Barrie Peck, Pedro Cutillas, Jude Fitzgibbon, Kevin Rouault-Pierre, Kamil Kranc & Paolo Gallipoli
Leukemia. 2024 Aug 26.
Winner: Paolo Gallipoli
Leukemia. 2024 Aug 26.
Winner: Thomas Powles
Clin Cancer Res. 2024 Sep 13;30(18):4115-4122.
Winner: Kevin Rouault-Pierre
Leukemia. 2024 Aug;38(8):1764-1776.
Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
Winner: Roberto Bellelli
Cell Rep. 2024 May 28;43(5):114205.
Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma
Winner: Tom Powles
N Engl J Med. 2024 Apr 18;390(15):1359-1371.
Winner: Kamil Kranc
Nat Cancer. 2024 Jun;5(6):916-937.
Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer
Winner: Tom Powles
N Engl J Med. 2024 Mar 7;390(10):875-888.
Winner: Peter Szlosarek
JAMA Oncol. 2024 Apr 1;10(4):475-483.
Isolation of Live Immune Cells from the Tumor Microenvironment by FACS
Winner: Luigi Ombrato
Methods Mol Biol. 2024;2748:1-12. doi: 10.1007/978-1-0716-3593-3_1.
Winner: Jessica Okosun
Blood Adv . 2023 Dec 1:bloodadvances.2023011426. doi: 10.1182/bloodadvances.2023011426.
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function
Winner: Richard Grose
J Pathol . 2024 Jan;262(1):90-104. doi: 10.1002/path.6214. Epub 2023 Nov 6.
S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer
Winner: Tatjana Crnogorac-Jurcevic
Oncogene. 2023 Nov;42(46):3422-3434. doi: 10.1038/s41388-023-02851-y. Epub 2023 Oct 4.
Winner: Daniel Berney
J Clin Oncol. 2023 Sep 8:JCO2300959
Winner: Gabriella Ficz and Emily Saunderson
Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2300224120. doi: 10.1073/pnas.2300224120. Epub 2023 Aug 14.
Winner: Susana Godinho, Pedro Monteiro and Bongwhan Yeon
EMBO J. 2023 Aug 15;42(16):e112812. doi: 10.15252/embj.2022112812. Epub 2023 Jul 5.
Winner: Richard Grose and Shayin Gibson
Matrix Biol. 2023 Jun 17;S0945-053X(23)00074-4. doi: 10.1016/j.matbio.2023.06.005.
Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis
Winner: Oliver Pearce and Eleanor Tyler
Nat. Commun. 2023 May 15;14(1):2514. doi: 10.1038/s41467-023-38093-5.
Winner: Paolo Gallipoli and Keith Woodley
Nat Commun. 2023 Apr 14;14(1):2132. doi: 10.1038/s41467-023-37652-0.
Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Winner: Richard Grose and Elena Tomas Bort
Elife. 2023 Mar 21;12:e86971. doi: 10.7554/eLife.86971.
Winner: Thomas Powles
J Clin Oncol. 2023 Feb 21;JCO2201414. doi: 10.1200/JCO.22.01414.
LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion.
Winner: Victoria Sanz-Moreno
Nat Cell Biol. 2023 Jan;25(1):108-119. doi: 10.1038/s41556-022-01042-3. Epub 2023 Jan 9.
Winner: Richard Grose
The evolutionary dynamics of extrachromosomal DNA in human cancers
Winner: Benjamin Werner
Nat Genet 54, 1527–1533 (2022). https://doi.org/10.1038/s41588-022-01177-x
MYC sensitises cells to apoptosis by driving energetic demand
Winner: Andy Finch
Nat Commun. 2022 Aug 9;13(1):4674. doi: 10.1038/s41467-022-32368-z.
Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer
Winner: Peter Schmid
N Engl J Med. 2022 Jul 21;387(3):217-226. doi: 10.1056/NEJMoa2202809.
Winner: John Gribben
Blood. 2022 Jun 9;blood.2021014375. doi: 10.1182/blood.2021014375.
Winners: Renato Baleeiro and Yaohe Wang
Oncoimmunology. 2022 May 27;11(1):2080329. doi: 10.1080/2162402X.2022.2080329. eCollection 2022.
Winner: Pedro Cutillas
Sci Signal. 2022 Apr 19;15(730):eabl7989. doi: 10.1126/scisignal.abl7989.
PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma
Winner: John Riches
J Clin Invest. 2022 Mar 22;e153436. doi: 10.1172/JCI153436.
Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer
Winner: Peter Schmid
N Engl J Med. 2022 Feb 10;386(6):556-567. doi: 10.1056/NEJMoa2112651.
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
Winners: Liz Murray, Shinelle Menezes & Angus Cameron
Cell Rep. 2022 Jan 25;38(4):110227. doi: 10.1016/j.celrep.2021.110227.
Winner: Thomas Powles
Nat Med. 2021 Dec;27(12):2200-2211. doi: 10.1038/s41591-021-01579-0. Epub 2021 Dec 10.
Winner: Stephen Duffy
Lancet Reg Health Eur. 2021 Sep 11;10:100179. doi: 10.1016/j.lanepe.2021.100179. eCollection 2021 Nov.
Winners: Hannah Lawson & Kamil Kranc
Stem Cell Reports. 2021 Nov 9;16(11):2784-2797. doi: 10.1016/j.stemcr.2021.10.001. Epub 2021 Oct 28.
Winners: Quentin Heydt & Bela Wrench
Nat Commun. 2021 Sep 17;12(1):5507. doi: 10.1038/s41467-021-25540-4.
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma
Winners: Oscar Maiques & Eva Crosas-Molist
Br J Cancer. 2021 Aug;125(5):699-713. doi: 10.1038/s41416-021-01442-6. Epub 2021 Jun 25.
Winner: Peter Schmid
Ann Oncol. 2021 Aug;32(8):983-993. doi: 10.1016/j.annonc.2021.05.355. Epub 2021 Jul 1.
ctDNA guiding adjuvant immunotherapy in urothelial carcinoma
Winner: Tom Powles
Nature. 2021 Jul;595(7867):432-437. doi: 10.1038/s41586-021-03642-9. Epub 2021 Jun 16.
Winner: Tom Powles
Nat Med. 2021 May;27(5):793-801. doi: 10.1038/s41591-021-01317-6. Epub 2021 May 3.
Winner: Owen Heath & Fran Balkwill
Cancer Immunol Res. 2021 Apr 10;canimm.0968.2020. doi: 10.1158/2326-6066.CIR-20-0968. Online ahead of print.
Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs
Winner: Henry Gerdes, Pedro Casado, Arran Dokal, Maruan Hijazi & Pedro Cutillas
Nat Commun. 2021 Mar 25;12(1):1850. doi: 10.1038/s41467-021-22170-8.
Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption
Winner: Sophie Adams & Susana Godinho
Curr Biol. 2021 Feb 9;S0960-9822(21)00061-0. doi: 10.1016/j.cub.2021.01.028. Online ahead of print.
CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma
Winner: Deepak Raj and John Marshall
Clin Cancer Res. 2021 Jan 21. doi: 10.1158/1078-0432.CCR-19-2163. Online ahead of print.
Winner: Silvana Debernardi and Tatjana Crnogorac-Jurcevic
PLoS Med. 2020 Dec 10;17(12):e1003489. doi: 10.1371/journal.pmed.1003489. eCollection 2020 Dec.
Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells
Winner: Maria Dermit & Faraz Mardakheh
Dev Cell. 2020 Nov 9;55(3):298-313.e10. doi: 10.1016/j.devcel.2020.10.006.
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
Winner: Irene Rodriguez-Hernandez and Victoria Sanz-Moreno
Nat Commun. 2020 Oct 20;11(1):5315. doi: 10.1038/s41467-020-18951-2.
Evolutionary dynamics of neoantigens in growing tumors
Winner: Eszter Lakatos & Trevor Graham
Nat Genet. (2020) Oct;52(10):1057-1066. doi: 10.1038/s41588-020-0687-1. Epub 2020 Sep 14.
Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma
Winner: Thomas Powles
N Engl J Med. (2020) Sep 24;383(13):1218-1230. doi: 10.1056/NEJMoa2002788. Epub 2020 Sep 18.
This paper also won Paper of the Year 2020
Winner: Stephen Duffy & Sue Moss
Lancet Oncol. (2020) Aug 12;S1470-2045(20)30398-3. doi: 10.1016/S1470-2045(20)30398-3. Online ahead of print.
Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation
Winner: Hemalvi Patani & Gabriela Ficz
Nat Commun 11, 3671 (2020). https://doi.org/10.1038/s41467-020-17269-3
Winner: Stephanie Kermorgant
Sci Signal (2020) 13(637):eaba8627. doi: 10.1126/scisignal.aba8627.
Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk With Tumor Cells
Winner: Ping-Pui Wong, José M Muñoz-Félix & Kairbaan Hodivala-Dilke
Cell (2020) May 28;S0092-8674(20)30147-1. doi: 10.1016/j.cell.2020.02.003. Online ahead of print.
This paper also won Paper of the Year 2020
Winner: Adam Brentnall
Int J Cancer. 2020 Apr 15;146(8):2122-2129. doi: 10.1002/ijc.32541. Epub 2019 Jul 13.
Cancer associated fibroblast FAK regulates malignant cell metabolism
Winner: Kairbaan Hodivala-Dilke & Fevzi Demircioglu
Nat Commun. 2020 Mar 10;11(1):1290. doi: 10.1038/s41467-020-15104-3.
Pembrolizumab for Early Triple-Negative Breast Cancer
Winner: Peter Schmid
N Engl J Med (2020) Feb 27;382(9):810-821. doi: 10.1056/NEJMoa1910549.
Winner: Pedro Cutillas
Nat Biotechnol (2020) Jan 20. doi: 10.1038/s41587-019-0391-9. [Epub ahead of print].
Winner: Peter Schmid
J Clin Oncol (2019) Dec 16:JCO1900368. doi: 10.1200/JCO.19.00368. [Epub ahead of print].
Winner: Jack Cuzick
Lancet (2019) Dec 11. pii: S0140-6736(19)32955-1. doi: 10.1016/S0140-6736(19)32955-1. [Epub ahead of print]
Winner: Yaohe Wang
Clin Cancer Res (2019) pii: clincanres.1395.2019. doi: 10.1158/1078-0432.CCR-19-1395.
A Cost-effectiveness Analysis of Multigene Testing for All Patients With Breast Cancer.
Winner: Li Sun & Ranjit Manchanda
JAMA Oncol (2019) Oct 3. doi: 10.1001/jamaoncol.2019.3323.
Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation.
Winner: Paulo Ribeiro
Elife (2019) Sep 30;8. pii: e46592. doi: 10.7554/eLife.46592.
Winner: Peter Schmid
JAMA Oncol. 2019 Aug 29. doi: 10.1001/jamaoncol.2019.2526. [Epub ahead of print]
Winner: Claire Reader and John Marshall
J Pathol. 2019 Jul 1. doi: 10.1002/path.5320. [Epub ahead of print]
Winner: Ana-Rita Pedrosa and Kairbaan Hodivala-Dilke
Cancer Research. June 12, 2019 doi: 10.1158/0008-5472.CAN-18-3934
Winner: Kamil Kranc
Cell Stem Cell. 2019 Jul 3;25(1):137-148.e6. doi: 10.1016/j.stem.2019.03.021. Epub 2019 Apr 25.
Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.
Winner: Tom Powles
N Engl J Med (2019) Mar 21;380(12):1116-1127. doi: 10.1056/NEJMoa1816714. Epub 2019 Feb 16.
Winner: Peter W. Szlosarek
Clin Cancer Res (2019) Feb 22. pii: clincanres.3729.2018. doi: 10.1158/1078-0432.CCR-18-3729. [Epub ahead of print]
Winner: Victoria Sanz-Moreno
Cell (2019), 176, 1–18 (article online ahead of press)
This paper also won Paper of the Year 2019
Winner: Cindy Neuzillet & Hemant M. Kocher
J Pathol (2018) Dec 21. doi: 10.1002/path.5224. [Epub ahead of print]
Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
Winner: Theresa Arnandis & Susana Godinho
Dev Cell (2018) Nov 19;47(4):409-424.e9. doi: 10.1016/j.devcel.2018.10.026.
Prp8 regulates oncogene-induced hyperplastic growth in Drosophila
Winner: Cecilia H. Fernández-Espartero & Paulo S. Ribeiro
Development (2018) Oct 17. pii: dev.162156. doi: 10.1242/dev.162156. [Epub ahead of print]
Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer
Winner: Peter Schmid
N Engl J Med (2018) Oct 20. doi: 10.1056/NEJMoa1809615. [Epub ahead of print]
Winner: Peter Schmid
JAMA Oncol (2018) Sep 13. doi: 10.1001/jamaoncol.2018.4224. [Epub ahead of print]
The evolutionary landscape of colorectal tumorigenesis
Winner: Will Cross & Trevor Graham
Nat Ecol Evol (2018) Aug 31. doi: 10.1038/s41559-018-0642-z. [Epub ahead of print]