Immunotherapy that improves response to chemotherapy in high-grade serous ovarian cancer.

Winner: Fran Balkwill

Nat Commun. 2024 Nov 22;15(1):10144.

---

The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma.

Winners: Jun 'Alex' Wang and Yaohe Wang

Nat Commun. 2024 Oct 18;15(1):8988

---

Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer

Winner: Thomas Powles

N Engl J Med. 2024 Nov 14;391(19):1773-1786.

---

Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer

Winner: Peter Schmid

N Engl J Med. 2024 Nov 28;391(21):1981-1991.

---

Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation

Winner: Paolo Gallipoli

Leukemia. 2024 Aug 26.

---

Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration Resistant Prostate Cancer

Winner: Thomas Powles

Clin Cancer Res. 2024 Sep 13;30(18):4115-4122.

---

Pivotal role of the endoplasmic reticulum stress-related XBP1s/miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy.

Winner: Kevin Rouault-Pierre

Leukemia. 2024 Aug;38(8):1764-1776.

---

Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors

Winner: Roberto Bellelli 

Cell Rep. 2024 May 28;43(5):114205.

---

Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma

Winner: Tom Powles

N Engl J Med. 2024 Apr 18;390(15):1359-1371.

---

The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia

Winner: Kamil Kranc

Nat Cancer. 2024 Jun;5(6):916-937.

---

Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer

Winner: Tom Powles

N Engl J Med. 2024 Mar 7;390(10):875-888.

---

Pegargiminase Plus First-Line Chemotherapy in Patients With Nonepithelioid Pleural Mesothelioma: The ATOMIC-Meso Randomized Clinical Trial

Winner: Peter Szlosarek

JAMA Oncol. 2024 Apr 1;10(4):475-483.

---

Isolation of Live Immune Cells from the Tumor Microenvironment by FACS

Winner: Luigi Ombrato

Methods Mol Biol. 2024;2748:1-12. doi: 10.1007/978-1-0716-3593-3_1.

Impact of Double Expression of MYC and BCL-2 on Outcomes in Primary CNS Lymphoma: A UK Multicentre Analysis

Winner: Jessica Okosun

Blood Adv . 2023 Dec 1:bloodadvances.2023011426. doi: 10.1182/bloodadvances.2023011426.

---

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function

Winner: Richard Grose

J Pathol . 2024 Jan;262(1):90-104. doi: 10.1002/path.6214. Epub 2023 Nov 6.

---

S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer

Winner: Tatjana Crnogorac-Jurcevic

Oncogene. 2023 Nov;42(46):3422-3434. doi: 10.1038/s41388-023-02851-y. Epub 2023 Oct 4.

---

Prognostic Factors for Relapse in Patients With Clinical Stage I Testicular Seminoma: A Nationwide, Population-Based Cohort Study

Winner: Daniel Berney

J Clin Oncol. 2023 Sep 8:JCO2300959

---

CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny

Winner: Gabriella Ficz and Emily Saunderson

Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2300224120. doi: 10.1073/pnas.2300224120. Epub 2023 Aug 14.

---

Centrosome amplification fine tunes tubulin acetylation to differentially control intracellular organization

Winner: Susana Godinho, Pedro Monteiro and Bongwhan Yeon

EMBO J. 2023 Aug 15;42(16):e112812. doi: 10.15252/embj.2022112812. Epub 2023 Jul 5.

---

ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation

Winner: Richard Grose and Shayin Gibson

Matrix Biol. 2023 Jun 17;S0945-053X(23)00074-4. doi: 10.1016/j.matbio.2023.06.005.

---

Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis

Winner: Oliver Pearce and Eleanor Tyler

Nat. Commun. 2023 May 15;14(1):2514. doi: 10.1038/s41467-023-38093-5.

---

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.

Winner: Paolo Gallipoli and Keith Woodley

Nat Commun. 2023 Apr 14;14(1):2132. doi: 10.1038/s41467-023-37652-0.

---

Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

Winner: Richard Grose and Elena Tomas Bort

Elife. 2023 Mar 21;12:e86971. doi: 10.7554/eLife.86971.

---

Phase II Study Investigating the Safety and Efficacy of Savolitinib and Durvalumab in Metastatic Papillary Renal Cancer (CALYPSO)

Winner: Thomas Powles

J Clin Oncol. 2023 Feb 21;JCO2201414. doi: 10.1200/JCO.22.01414.

---

LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion.

Winner: Victoria Sanz-Moreno

Nat Cell Biol. 2023 Jan;25(1):108-119. doi: 10.1038/s41556-022-01042-3. Epub 2023 Jan 9.

 

Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1

Winner: Richard Grose

The evolutionary dynamics of extrachromosomal DNA in human cancers

Winner: Benjamin Werner

Nat Genet 54, 1527–1533 (2022). https://doi.org/10.1038/s41588-022-01177-x

---

MYC sensitises cells to apoptosis by driving energetic demand

Winner: Andy Finch

Nat Commun. 2022 Aug 9;13(1):4674. doi: 10.1038/s41467-022-32368-z.

---

Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer

Winner: Peter Schmid

N Engl J Med. 2022 Jul 21;387(3):217-226. doi: 10.1056/NEJMoa2202809.

---

Comparative effectiveness of ZUMA-5 (axi-cel) vs SCHOLAR-5 external control in relapsed/refractory follicular lymphoma

Winner: John Gribben

Blood. 2022 Jun 9;blood.2021014375. doi: 10.1182/blood.2021014375.

---

MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapy

Winners: Renato Baleeiro and Yaohe Wang

Oncoimmunology. 2022 May 27;11(1):2080329. doi: 10.1080/2162402X.2022.2080329. eCollection 2022.

---

Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment

Winner: Pedro Cutillas

Sci Signal. 2022 Apr 19;15(730):eabl7989. doi: 10.1126/scisignal.abl7989.

---

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

Winner: John Riches

J Clin Invest. 2022 Mar 22;e153436. doi: 10.1172/JCI153436.

---

Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer

Winner: Peter Schmid

N Engl J Med. 2022 Feb 10;386(6):556-567. doi: 10.1056/NEJMoa2112651.

---

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

Winners: Liz Murray, Shinelle Menezes & Angus Cameron

Cell Rep. 2022 Jan 25;38(4):110227. doi: 10.1016/j.celrep.2021.110227.

---

Avelumab maintenance in advanced urothelial carcinoma: biomarker analysis of the phase 3 JAVELIN Bladder 100 trial

Winner: Thomas Powles

Nat Med. 2021 Dec;27(12):2200-2211. doi: 10.1038/s41591-021-01579-0. Epub 2021 Dec 10.

---

Lung cancer mortality reduction by LDCT screening: UKLS randomised trial results and international meta-analysis

Winner: Stephen Duffy

Lancet Reg Health Eur. 2021 Sep 11;10:100179. doi: 10.1016/j.lanepe.2021.100179. eCollection 2021 Nov.

---

CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation

Winners: Hannah Lawson & Kamil Kranc

Stem Cell Reports. 2021 Nov 9;16(11):2784-2797. doi: 10.1016/j.stemcr.2021.10.001. Epub 2021 Oct 28.

---

Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

Winners: Quentin Heydt & Bela Wrench

Nat Commun. 2021 Sep 17;12(1):5507. doi: 10.1038/s41467-021-25540-4.

---

A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma

Winners: Oscar Maiques & Eva Crosas-Molist

Br J Cancer. 2021 Aug;125(5):699-713. doi: 10.1038/s41416-021-01442-6. Epub 2021 Jun 25.

---

First-line atezolizumab plus nab-paclitaxel for unresectable, locally advanced, or metastatic triple-negative breast cancer: IMpassion130 final overall survival analysis.

Winner: Peter Schmid

Ann Oncol. 2021 Aug;32(8):983-993. doi: 10.1016/j.annonc.2021.05.355. Epub 2021 Jul 1.

---

ctDNA guiding adjuvant immunotherapy in urothelial carcinoma

Winner: Tom Powles

Nature. 2021 Jul;595(7867):432-437. doi: 10.1038/s41586-021-03642-9. Epub 2021 Jun 16.

---

An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer

Winner: Tom Powles

Nat Med. 2021 May;27(5):793-801. doi: 10.1038/s41591-021-01317-6. Epub 2021 May 3.

---

Chemotherapy induces tumor-associated macrophages that aid adaptive immune responses in ovarian cancer

Winner: Owen Heath & Fran Balkwill

Cancer Immunol Res. 2021 Apr 10;canimm.0968.2020. doi: 10.1158/2326-6066.CIR-20-0968. Online ahead of print.

---

Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs

Winner: Henry Gerdes, Pedro Casado, Arran Dokal, Maruan Hijazi & Pedro Cutillas

Nat Commun. 2021 Mar 25;12(1):1850. doi: 10.1038/s41467-021-22170-8.

---

Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption

Winner: Sophie Adams & Susana Godinho

Curr Biol. 2021 Feb 9;S0960-9822(21)00061-0. doi: 10.1016/j.cub.2021.01.028. Online ahead of print.

---

CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma

Winner: Deepak Raj and John Marshall

Clin Cancer Res. 2021 Jan 21. doi: 10.1158/1078-0432.CCR-19-2163. Online ahead of print.

A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case-control study

Winner: Silvana Debernardi and Tatjana Crnogorac-Jurcevic

PLoS Med. 2020 Dec 10;17(12):e1003489. doi: 10.1371/journal.pmed.1003489. eCollection 2020 Dec.

---

Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells

Winner: Maria Dermit & Faraz Mardakheh

Dev Cell. 2020 Nov 9;55(3):298-313.e10. doi: 10.1016/j.devcel.2020.10.006.

---

WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion

Winner: Irene Rodriguez-Hernandez and Victoria Sanz-Moreno

Nat Commun. 2020 Oct 20;11(1):5315. doi: 10.1038/s41467-020-18951-2.

---

Evolutionary dynamics of neoantigens in growing tumors

Winner: Eszter Lakatos & Trevor Graham

Nat Genet. (2020) Oct;52(10):1057-1066. doi: 10.1038/s41588-020-0687-1. Epub 2020 Sep 14.

---

Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma

Winner: Thomas Powles

N Engl J Med. (2020) Sep 24;383(13):1218-1230. doi: 10.1056/NEJMoa2002788. Epub 2020 Sep 18.

This paper also won Paper of the Year 2020

---

Effect of mammographic screening from age 40 years on breast cancer mortality (UK Age trial): final results of a randomised, controlled trial.

Winner: Stephen Duffy & Sue Moss

Lancet Oncol. (2020) Aug 12;S1470-2045(20)30398-3. doi: 10.1016/S1470-2045(20)30398-3. Online ahead of print.

---

Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation

Winner: Hemalvi Patani & Gabriela Ficz

Nat Commun 11, 3671 (2020). https://doi.org/10.1038/s41467-020-17269-3

---

A PI3K- and GTPase-independent Rac1-mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration

Winner: Stephanie Kermorgant

Sci Signal (2020) 13(637):eaba8627. doi: 10.1126/scisignal.aba8627. 

---

Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk With Tumor Cells

Winner: Ping-Pui Wong, José M Muñoz-Félix & Kairbaan Hodivala-Dilke

Cell (2020) May 28;S0092-8674(20)30147-1. doi: 10.1016/j.cell.2020.02.003. Online ahead of print.

This paper also won Paper of the Year 2020

---

A case-control evaluation of 143 single nucleotide polymorphisms for breast cancer risk stratification with classical factors and mammographic density

Winner: Adam Brentnall

Int J Cancer. 2020 Apr 15;146(8):2122-2129. doi: 10.1002/ijc.32541. Epub 2019 Jul 13.

---

Cancer associated fibroblast FAK regulates malignant cell metabolism

Winner: Kairbaan Hodivala-Dilke & Fevzi Demircioglu 

Nat Commun. 2020 Mar 10;11(1):1290. doi: 10.1038/s41467-020-15104-3.

---

Pembrolizumab for Early Triple-Negative Breast Cancer

Winner: Peter Schmid

N Engl J Med (2020) Feb 27;382(9):810-821. doi: 10.1056/NEJMoa1910549.

---

Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring.

Winner: Pedro Cutillas

Nat Biotechnol (2020) Jan 20. doi: 10.1038/s41587-019-0391-9. [Epub ahead of print].

Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial.

Winner: Peter Schmid

J Clin Oncol (2019) Dec 16:JCO1900368. doi: 10.1200/JCO.19.00368. [Epub ahead of print].

---

Use of anastrozole for breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial.

Winner: Jack Cuzick 

Lancet (2019) Dec 11. pii: S0140-6736(19)32955-1. doi: 10.1016/S0140-6736(19)32955-1. [Epub ahead of print]

---

A Virus-Infected, Reprogrammed Somatic cell-derived Tumor cell (VIReST) vaccination regime can prevent initiation and progression of pancreatic cancer.

Winner: Yaohe Wang

Clin Cancer Res (2019) pii: clincanres.1395.2019. doi: 10.1158/1078-0432.CCR-19-1395.

---

A Cost-effectiveness Analysis of Multigene Testing for All Patients With Breast Cancer.

Winner: Li Sun & Ranjit Manchanda

JAMA Oncol (2019) Oct 3. doi: 10.1001/jamaoncol.2019.3323.

---

Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation.

Winner: Paulo Ribeiro

Elife (2019) Sep 30;8. pii: e46592. doi: 10.7554/eLife.46592.

---

Fulvestrant Plus Vistusertib vs Fulvestrant Plus Everolimus vs Fulvestrant Alone for Women With Hormone Receptor-Positive Metastatic Breast Cancer: The MANTA Phase 2 Randomized Clinical Trial.

Winner: Peter Schmid

JAMA Oncol. 2019 Aug 29. doi: 10.1001/jamaoncol.2019.2526. [Epub ahead of print]

---

The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

Winner: Claire Reader and John Marshall

J Pathol. 2019 Jul 1. doi: 10.1002/path.5320. [Epub ahead of print]

---

Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861

Winner: Ana-Rita Pedrosa and Kairbaan Hodivala-Dilke

Cancer Research. June 12, 2019 doi: 10.1158/0008-5472.CAN-18-3934

---

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukaemia

Winner: Kamil Kranc

Cell Stem Cell. 2019 Jul 3;25(1):137-148.e6. doi: 10.1016/j.stem.2019.03.021. Epub 2019 Apr 25.

---

Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

Winner: Tom Powles

N Engl J Med (2019) Mar 21;380(12):1116-1127. doi: 10.1056/NEJMoa1816714. Epub 2019 Feb 16.

---

A Phase I study of pegylated arginine deiminase (pegargiminase), cisplatin and pemetrexed in argininosuccinate synthetase 1-deficient recurrent high-grade glioma

Winner: Peter W. Szlosarek

Clin Cancer Res (2019) Feb 22. pii: clincanres.3729.2018. doi: 10.1158/1078-0432.CCR-18-3729. [Epub ahead of print]

---

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

Winner: Victoria Sanz-Moreno

Cell (2019), 176, 1–18 (article online ahead of press)

This paper also won Paper of the Year 2019

Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

Winner: Cindy Neuzillet & Hemant M. Kocher

J Pathol (2018) Dec 21. doi: 10.1002/path.5224. [Epub ahead of print]

---

Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion

Winner: Theresa Arnandis & Susana Godinho

Dev Cell (2018) Nov 19;47(4):409-424.e9. doi: 10.1016/j.devcel.2018.10.026.

---

Prp8 regulates oncogene-induced hyperplastic growth in Drosophila

Winner: Cecilia H. Fernández-Espartero & Paulo S. Ribeiro

Development (2018) Oct 17. pii: dev.162156. doi: 10.1242/dev.162156. [Epub ahead of print]

---

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

Winner: Peter Schmid

N Engl J Med (2018) Oct 20. doi: 10.1056/NEJMoa1809615. [Epub ahead of print]

---

Long-term Clinical Outcomes and Biomarker Analyses of Atezolizumab Therapy for Patients With Metastatic Triple-Negative Breast Cancer: A Phase 1 Study

Winner: Peter Schmid

JAMA Oncol (2018) Sep 13. doi: 10.1001/jamaoncol.2018.4224. [Epub ahead of print]

---

The evolutionary landscape of colorectal tumorigenesis

Winner: Will Cross & Trevor Graham

Nat Ecol Evol (2018) Aug 31. doi: 10.1038/s41559-018-0642-z. [Epub ahead of print]