Acute myeloid leukaemia familial cases, where two or more affected individuals are found in the same family, are rare but represent a high-risk group of patients who require a unique management.

My research project aims to identify germline mutations in families with leukaemia of unknown aetiology and study the intra and inter leukaemia heterogeneity observed in these families, through an examination of the clonal evolution and secondary genetic events.

The project will lead to a fundamental change in the understanding of familial AML and a step forward in management of this group of life threatening diseases.

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