Dr Rifca Le Dieu

MB BS, FRCP, PhD
Clinical Reader
Fellow of the Higher Education Academy
Group Leader
Email Staff Directory
Teaching Focus

I have a teaching role within Barts Cancer Institute. I am the Module Lead for 3 undergraduate Biomedical Science Modules: Tissue Biology for Year 1, Cellular Pathology and Blood Science for Year 3 and the elective Year 3 module, Molecular Basis of Personalised Medicine. I am also the Cancer Theme Lead for MBBS with direct responsibility for Year 2 Cancer Week. In addition, I supervise MSc project dissertations.

Other Activities
  • Barts Health NHS Trust Champion of Flexible Working
  • Joint Deputy Director of the Royal College of Physicians’ Medical Workforce Unit
  • Member of the Hodgkins Lymphoma NCRI Clinical Trials Subgroup
Themes/Keywords
Clinical Trials Immunotherapy Blood Leukaemia Centre for Haemato-Oncology
Other Activities
  • Barts Health NHS Trust Champion of Flexible Working
  • Joint Deputy Director of the Royal College of Physicians’ Medical Workforce Unit
  • Member of the Hodgkins Lymphoma NCRI Clinical Trials Subgroup
Recent Publications

Clinical Outcome of Coronavirus Disease 2019 in Haemato-oncology Patients. Aries JA, Davies JK, Auer RL et al. British Journal of Haematology (2020) (1)
https://www.ncbi.nlm.nih.gov/pubmed/32420609

EBMT risk score predicts outcome of allogeneic hematopoietic stem cell transplantation in patients who have failed a previous transplantation procedure. Rezvani K, Kanfer EJ, Marin D et al. Biol Blood Marrow Transplant (2012) 18(1) 235-240

Array-based DNA methylation profiling in follicular lymphoma O'Riain C, O'Shea DM, Yang Y et al. Leukemia (2009) 23(1) 1858-1866

Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts Le Dieu R, Taussig D, Ramsay AG et al. Blood (2009) 114(1) 3909-3916

Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts Le Dieu R, Taussig DC, Ramsay AG et al. Blood (2009) 114(10) 3909-3916

Negative immunomagnetic selection of T cells from peripheral blood of presentation AML specimens Le Dieu R, Taussig D, Lister TA et al. Journal of Immunological Methods (2009) 348(1) 95-100

E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction Gorgun G, Ramsay AG, Holderried TAW et al. PNAS (2009) 106(1) 6250-6255

Differential Gene Expression Profile Identifies the Nature of T Cell Defects in AML Patients at Diagnosis. Le Dieu R, Ramsay AG, Taussig D et al. Blood (2008) 112(10) 1186

Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. Ramsay AG, Johnson AJ, Lee AM et al. J Clin Invest (2008) 118(2) 2427-2437
https://www.ncbi.nlm.nih.gov/pubmed/18551193

Chronic Lymphocytic Leukaemia Le Dieu R, Gribben JG (2008) (1)

For additional publications, please click here
Biography

I am an Honorary Consultant at Barts Health NHS Trust where I have a lymphoma practice. I trained at St John’s College, Cambridge and Imperial College, London before completing Haematology specialist training in NW London. My subsequent research focused on the microenvironment in cancer and I completed a PhD and subsequent post-doctoral research in Professor John Gribben’s group.

Since joining Barts, I have taken an active interest in clinical trials and joined the NCRI Hodgkins Lymphoma subgroup. I speak at the Lymphoma Action Management Course on relapsed Hodgkin’s lymphoma.

I am a passionate advocate of flexible working for medical staff via my dual roles as Barts Health Champion of Flexible Working and Joint Deputy Director of the Royal College of Physicians’ Medical Workforce Unit.

Over the course of my medical career, I have developed a keen interest in teaching which my role at Barts Cancer Institute has allowed me to progress. I am particularly interested in new ways of delivering teaching and also cultivating good teachers.