Our group is interested in epigenetic regulation of somatic mutagenesis in normal and malignant B cells. Specifically, we aim to understand how alterations in the nuclear envelope influence B cell chromatin conformation, and what the epigenetic consequences of these alterations are.
Lamin B1 regulates somatic mutations and progression of B-cell malignancies. Leukemia (2018) 32(2):364-375. PMID: 28804121
Autophagy mediates degradation of nuclear lamina. Nature (2015) 527(7576):105-9. PMID: 26524528
Lysosome-mediated processing of chromatin in senescence. J Cell Biol (2013) 202(1):129-43. PMID: 23816621
Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies. Blood (2011) 117(17):4519-29. PMID: 21378274
Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J Clin Invest (2009) 119(8):2143-59. PMID: 1962078
Our group is interested in epigenetic regulation of somatic mutagenesis in normal and malignant B cells. Specifically, we aim to understand how alterations in the nuclear envelope influence B cell chromatin conformation, and what the epigenetic consequences of these alterations are.
At a systemic level, we are interested in how the lamina-associated chromatin domain (LAD) dynamics influence normal adaptive immunity, and whether dysregulation of this mechanism leads to autoimmunity and cancer.
From a translational perspective, we are aiming to develop novel therapeutic strategies to target nuclear lamina, establishing a new generation of treatment modalities of malignant lymphoma.
Stromal cell inhibition of anti-CD20 antibody mediated killing of B-cell malignancies Fagnano E, Pendharkar S, Colton M et al. Frontiers in Cell and Developmental Biology 11(10) 1270398
A comprehensive method to study the DNA's association with lamin and chromatin compaction in intact cell nuclei at super resolution Chapman KB, Filipsky F, Peschke N et al. Nanoscale (2023) 15(10) 742-756
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia Bloehdorn J, Braun A, Taylor-Weiner A et al. Nature Communications (2021) 12(1)
Rituximab and obinutuzumab differentially hijack the B-cell receptor and NOTCH1 signaling pathways. Edelmann J, Dokal AD, Vilventhraraja E et al. iScience (2021) (1) 102089-102089
Multiplatform Profiling Characterizes Functional Networks in Genomically Stable and Instable Chronic Lymphocytic Leukemia Bloehdorn J, Braun A, Jebaraj BMC et al. Blood (2020) 136(1) 12-13
Anti-CD20 Monoclonal Antibodies Hijack the B-Cell Receptor Signaling Cascade Thereby Activating the NOTCH1 Signaling Pathway Edelmann J, Britton DJ, Vilventhraraja E et al. Blood (2018) 132(1) 588-588
Lamin B1 regulates somatic mutations and progression of B-cell malignancies. Klymenko T, Bloehdorn J, Bahlo J et al. Leukemia 32(1) 364-375
https://www.ncbi.nlm.nih.gov/pubmed/28804121
NUCLEAR LAMINA REGULATES SOMATIC HYPERMUTATION AND PROGRESSION OF B CELL MALIGNANCIES Klymenko T, Bloehdorn J, Bahlo J et al. HAEMATOLOGICA (2017) 102(1) 228-228
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ONCOGENE-EXPRESSING SENESCENT MELANOCYTES UPREGULATE MHC CLASS II, A CANDIDATE MELANOMA SUPPRESSOR FUNCTION BRAUNS A Journal of Investigative Dermatology (1)
Rituximab Activates NOTCH1 Signaling in CLL Cells and Induces Changes in the Cytokine Repertoire Favoring a Tumor-Protective Microenvironment Edelmann J, Holzmann K, DiBella D et al. BLOOD (2017) 130(11)
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