Our group investigates cancer evolution, with a focus on understanding how genetic changes influence disease progression, response to therapy and development of resistance. We particularly concentrate on gastrointestinal cancers such as colorectal, stomach and oesophageal cancer.
We employ advanced computational techniques to analyse tumour samples, generating complex molecular data at the level of individual cells. These data help us predict tumour behaviour and patient outcomes. Additionally, we explore how the tumour microenvironment, including the immune system, interacts with cancer genetics, expanding our understanding of cancer evolution.
We collaborate closely with clinicians to analyse clinical trial data to better understand how different individuals respond to treatments. Ultimately, all of our work aims to benefit patients and reveal opportunities to develop more effective cancer therapies.
Our group investigates cancer evolution, with a focus on understanding how genetic changes influence disease progression, response to therapy and development of resistance. We particularly concentrate on gastrointestinal cancers such as colorectal, stomach and oesophageal cancer.
We employ advanced computational techniques to analyse tumour samples, generating complex molecular data at the level of individual cells. These data help us predict tumour behaviour and patient outcomes. Additionally, we explore how the tumour microenvironment, including the immune system, interacts with cancer genetics, expanding our understanding of cancer evolution.
We collaborate closely with clinicians to analyse clinical trial data to better understand how different individuals respond to treatments. Ultimately, all of our work aims to benefit patients and reveal opportunities to develop more effective cancer therapies.
In 2014, I joined King's College London as Associate Professor (Reader) in Cancer Genomics and Bioinformatics. From 2015, I coordinated the Quantitative Genomics, Epigenomics, and Biobank Programme in the Division of Cancer Studies at King's. I was appointed as Professor of Cancer Genomics at King's College London in 2018.
I moved to the Barts Cancer Institute at Queen Mary University of London in 2023 where I now lead the Centre for Cancer Genomics and Computational Biology. I have also been a seconded group leader at the Francis Crick Institute since 2017, and I continue to hold a lab there.