Professor Peter Schmid

FRCP, MD, PhD
Professor of Cancer Medicine; Centre Lead, Centre of Experimental Cancer Medicine; Director, Barts Breast Cancer Centre
Centre Lead, Group Leader
Research Focus

My research interests focus on improving the care of women with breast cancer through clinical trials. I lead a spectrum of clinical studies spanning the spectrum of the disease and ranging from phase I to randomised phase III. The majority of these studies are translational phase II studies investigating novel targeted and immune therapies. Our current interests include cancer immune therapy combinations across all stages and subtypes of breast cancer, novel targeted agents and antibody-drug conjugates - alone or in combination - to overcome resistance, and innovative biomarker-driven trial concepts (including a preoperative window of opportunity platform to evaluate novel immunotherapy combinations in breast cancer).

Key Publications

Pembrolizumab for Early Triple-Negative Breast Cancer. N Engl J Med (2020) 382(9):810-821. PMID: 32101663

Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial. Lancet (2020) 396(10265):1817-1828. PMID: 33278935

Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol (2020) 21(1):44-59. PMID: 31786121

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer. N Engl J Med (2018) 379(22):2108-2121. PMID: 30345906

 

Major Funding
  • BARBICAN: A randomised, open-label Phase II study to determine the contribution of ipatasertib to neoadjuvant chemotherapy plus atezolizumab in women with TNBC (CI). Roche, 2018-2022
  • ECLIPSE: A phase II trial investigating preoperative combination strategies for immunotherapy in patients with operable, ER-positive, HER2-negative primary breast cancer (CI). Roche, 2017-2022
  • Barts Experimental Cancer Medicine Centre (PI). Cancer Research UK and NIHR. 2017-2022, £2M
  • Comprehensive Analysis of Circulating Biomarkers in breast cancer patients (CI). Barts Charity, 2015-2022, £499,652
Other Activities
  • Clinical director, Barts Breast Cancer Centre, St Bartholomew's Hospital
  • Chair, European Society for Medical Oncology (ESMO) breast cancer faculty
  • Scientific committee/faculty for the major global oncology meetings
  • ECMC strategy group and ECMC Intelligence Steering Committee
  • Clinical Expert for the UK National Institute for Health and Clinical Excellence (NICE), nominated by the Royal College of Physicians
  • International guidelines for breast cancer
Research

Professor Schmid’s research is focused on improving the care of women with breast cancer through clinical trials. He is investigating a variety of novel agents that target specific pathways within cancer cells and the surrounding tissue. Professor Schmid runs an international clinical and translational research programme spanning the spectrum of the disease and ranging from phase I to randomised phase III. The majority of the studies incorporate translational research endpoints to improve our understanding of molecular factors that may elucidate mechanisms of action and predictors of treatment effect; this includes a programme on the impact of the microbiome on patient outcomes.

His current research interests include cancer immune therapy combinations across all stages and subtypes of breast cancer, novel targeted agents and antibody-drug conjugates - alone or in combination - to overcome resistance, and innovative biomarker-driven trial concepts (including a preoperative window of opportunity platform to evaluate novel immunotherapy combinations in breast cancer).

Professor Schmid is the lead investigator of several international, pivotal breast cancer studies on novel targeted therapeutics to improve the treatment of both early and late stage breast cancer. He was the lead investigator of the Impassion130 trial that evaluated atezolizumab for advanced triple-negative breast cancer and lead to the approval of the first immunotherapy strategy for patients with breast cancer, establishing a new standard of care for this disease. He was also the lead investigator of the KEYNOTE-522 trial which established the addition of the immune-checkpoint inhibitor Pembrolizumab to preoperative chemotherapy as a new standard for patients with stage II or III triple-negative breast cancer based on a 37% reduction in recurrences of this aggressive subtype of breast cancer.

Professor Schmid’s work has published over 100 peer-reviewed papers in medical journals, including the New England Journal of Medicine, Lancet, Lancet Oncology, JAMA Oncology, Nature Communications and the Journal of Clinical Oncology. He has grant income from national and international funding bodies.

Prof Schmid is a member of several national and international cancer organisations and research groups. He has been involved in international consensus meetings and is co-author of international guidelines on the management of breast cancer. Professor Peter Schmid is Chair of the European Society for Medical Oncology (ESMO) breast cancer faculty and he is part of the faculty for the major global oncology meetings.

Other Activities
  • Clinical director, Barts Breast Cancer Centre, St Bartholomew's Hospital
  • Chair, European Society for Medical Oncology (ESMO) breast cancer faculty
  • Scientific committee/faculty for the major global oncology meetings
  • ECMC strategy group and ECMC Intelligence Steering Committee
  • Clinical Expert for the UK National Institute for Health and Clinical Excellence (NICE), nominated by the Royal College of Physicians
  • International guidelines for breast cancer
Major Funding
  • BARBICAN: A randomised, open-label Phase II study to determine the contribution of ipatasertib to neoadjuvant chemotherapy plus atezolizumab in women with TNBC (CI). Roche, 2018-2022
  • ECLIPSE: A phase II trial investigating preoperative combination strategies for immunotherapy in patients with operable, ER-positive, HER2-negative primary breast cancer (CI). Roche, 2017-2022
  • Barts Experimental Cancer Medicine Centre (PI). Cancer Research UK and NIHR. 2017-2022, £2M
  • Comprehensive Analysis of Circulating Biomarkers in breast cancer patients (CI). Barts Charity, 2015-2022, £499,652
  • ARB-ER - Randomized Phase II window study of short-term preoperative treatment with enzalutamide plus exemestane versus exemestane in ER-positive breast cancer (CI). Astellas, 2014-2017
  • ARB-TNBC - Phase II window study of short-term preoperative treatment with enzalutamide in patients with triple negative breast cancer (CI). Astellas, 2014-2017
  • MANTA - Randomized Phase II study of Fulvestrant in combination with AZD2014 or Everolimus or Fulvestrant alone in ER-positive metastatic breast cancer (CI). Astra Zeneca, 2013-2018
  • CRUKE/12/051: PAKT - Phase II, randomized, placebo-controlled study of paclitaxel +/- the AKT inhibitor AZD5363 in triple-negative breast cancer (CI). CRUK/Astra Zeneca, 2013-2018
Recent Publications

Pembrolizumab Plus Chemotherapy Followed by Pembrolizumab in Patients With Early Triple-Negative Breast Cancer Takahashi M, Cortés J, Dent R et al. JAMA Network Open (2023) 6(10) e2342107

Impact of pembrolizumab versus chemotherapy on health-related quality of life in patients with metastatic triple-negative breast cancer: results from the phase 3 randomised KEYNOTE-119 study Schmid P, Lipatov O, Im S-A et al. European Journal of Cancer (2023) 195(10) 113393

Neoadjuvant immunotherapy and chemotherapy regimens for the treatment of high-risk, early-stage triple-negative breast cancer: a systematic review and network meta-analysis Cortes J, Haiderali A, Huang M et al. BMC Cancer 23(10) 792

Overall survival with sacituzumab govitecan in hormone receptor-positive and human epidermal growth factor receptor 2-negative metastatic breast cancer (TROPiCS-02): a randomised, open-label, multicentre, phase 3 trial Rugo HS, Bardia A, Marmé F et al. The Lancet (2023) 402(10) 1423-1433

ESMO Expert Consensus Statements on the management of breast cancer during pregnancy (PrBC) Loibl S, Azim HA, Bachelot T et al. Annals of Oncology (2023) 34(10) 849-866

TROPION-Breast02: Datopotamab deruxtecan for locally recurrent inoperable or metastatic triple-negative breast cancer Dent RA, Cescon DW, Bachelot T et al. Future Oncology (2023) 19(10) 2349-2359

XENERA-1: a randomised double-blind Phase II trial of xentuzumab in combination with everolimus and exemestane versus everolimus and exemestane in patients with hormone receptor-positive/HER2-negative metastatic breast cancer and non-visceral disease Schmid P, Cortes J, Joaquim A et al. Breast Cancer Research (2023) 25(10) 67

ESMO expert consensus statements (ECS) on the definition, diagnosis, and management of HER2-low breast cancer Tarantino P, Viale G, Press MF et al. Annals of Oncology (2023) 34(10) 645-659

Evaluation of triple negative breast cancer with heterogeneous immune infiltration Quintana Á, Arenas EJ, Bernadó C et al. Frontiers in Immunology 14(10) 1149747

Prognostic and predictive impact of gene expression in node‐positive early breast cancer patients receiving dose‐dense versus standard‐dose adjuvant chemotherapy Reinisch M, Bruzas S, Gluz O et al. Molecular Oncology (2023) 17(10) 1060-1075

For additional publications, please click here
Biography

Professor Schmid is the clinical director of the Breast Cancer Centre and an honorary consultant medical oncologist at St. Bartholomew’s Hospital. He was appointed in 2013 as Chair in Cancer Medicine at Barts Cancer Institute (BCI), Queen Mary University London. Professor Schmid is the Lead of the Centre of Experimental Cancer Medicine at BCI, overseeing the conduct of early phase trials at St. Bartholomew’s Hospital and BCI. He leads the academic breast cancer programme at St. Bartholomew’s Hospital and BCI.

Professor Schmid trained in medicine in Munich and Aberdeen. He was awarded scholarships by the 'Studienstiftung des deutschen Volkes' (German Academic Scholarship Foundation), the 'Hanns-Seidel-Foundation', and the 'Deutscher Akademischer Austauschdienst' (German Academic Exchange Service). He graduated from the Technical University of Munich medical school in 1997, gaining a MD in Clinical Chemistry in 1998 from the University of Munich and a Clinical Research PhD in 2005 from Charité University in Berlin.

Prof Schmid trained at the University Hospital Charité in Berlin in internal medicine, haematology, and oncology, before he became a Senior Clinical Lecturer and Director of the Hammersmith Early Clinical Trials Unit at Imperial College London in 2005. Professor Schmid was appointed as Foundation Chair in Cancer Medicine at the University of Sussex in 2010, before taking on his current role at BCI in 2013.